Rifampin Heteroresistance in Mycobacterium tuberculosis Cultures as Detected by Phenotypic and Genotypic Drug Susceptibility Test Methods
نویسندگان
چکیده
منابع مشابه
Comparison of different drug susceptibility test methods to detect rifampin heteroresistance in Mycobacterium tuberculosis.
We compared the efficiencies of different drug susceptibility testing methods in detecting rifampin (RIF) heteroresistance in Mycobacterium tuberculosis. Our data revealed that the broth dilution method found more resistance than MGIT did (P=0.046) for the low-resistance group. Similarly, the broth dilution method was more sensitive in detecting RIF heteroresistance in subpopulations with low g...
متن کاملComparison of different drug susceptibility test methods to detect the 1 rifampin heteroresistance in Mycobacterium tuberculosis
23 We compared the efficiency of different drug susceptibility testing methods to detect 24 the rifampin (RIF) heteroresistance in Mycobacterium tuberculosis. Our data revealed 25 that broth dilution method found more resistance than MGIT (P=0.046) for low 26 resistance group. Similarly, broth dilution method was more sensitive to detect RIF 27 heteroresistance in subpopulation with slow grow r...
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The objectives of this study were to investigate the origin of highly discordant rifampin (rifampicin) (RMP) drug susceptibility test results obtained for Mycobacterium tuberculosis strains during proficiency testing. Nine Supra-National Tuberculosis Reference Laboratories tested the RMP susceptibilities of 19 selected M. tuberculosis strains, using standard culture-based methods. The strains w...
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Mycobacterium tuberculosis converts pyrazinamide to its active form by using the enzyme pyrazinamidase. This enzyme is coded for on the pncA gene, and mutations in the pncA gene result in absence of active enzyme, conferring resistance to the drug pyrazinamide. We investigated 27 strains of Mycobacterium tuberculosis suspected of being multidrug resistant. Each isolate was tested for susceptibi...
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habitat overlaps with that of pteropid bats in southern Vietnam. Previous studies showed that IgG ELISA results for NiV-positive fl ying foxes correlated well with NT results (3,4). However, in our study, discrepancies existed between NT results and NiV-N-ELISA and WB results. A reason for these differences could be that Nipah-like viruses are circulating among bats in Vietnam, producing antibo...
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ژورنال
عنوان ژورنال: Journal of Clinical Microbiology
سال: 2013
ISSN: 0095-1137
DOI: 10.1128/jcm.01602-13